UK T1D Research Consortium Publications

You are here: / / UK T1D Research Consortium Publications

Selected publications

Please add the following sentence to acknowledge the UK-T1D-RC in all Consortium-related articles, papers and publications:
“This work was conducted in collaboration with the UK T1D-Research Consortium: https://type1diabetesresearch.org.uk/ ”

Papers published in 2023

Exocrine Proteins Including Trypsin(ogen) as a Key Biomarker in Type 1 Diabetes.

Bakinowska L, Vartak T, Phuthego T, Taylor M, Chandler K, Jerram ST, Williams S, Feldmann M, Johnson DG, Patel KA, Williams AJK, Long AE, Leslie RD, Gillespie KM; Action LADA Consortium; BOX Study Group.Diabetes Care. 2023 Apr 1;46(4):714-721. doi: 10.2337/dc22-1317.PMID: 36701208.

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes.

Van Rampelbergh J, Achenbach P, Leslie RD, Ali MA, Dayan C, Keymeulen B, Owen KR, Kindermans M, Parmentier F, Carlier V, Ahangarani RR, Gebruers E, Bovy N, Vanderelst L, Van Mechelen M, Vandepapelière P, Boitard C.BMC Med. 2023 May 24;21(1):190. doi: 10.1186/s12916-023-02900-z.

National Trends in Hyperglycemia and Diabetic Ketoacidosis in Children, Adolescents, and Young Adults With Type 1 Diabetes: A Challenge Due to Age or Stage of Development, or Is New Thinking About Service Provision Needed?

Holman N, Woch E, Dayan C, Warner J, Robinson H, Young B, Elliott J.Diabetes Care. 2023 Jul 1;46(7):1404-1408. doi: 10.2337/dc23-0180.

Age of Diagnosis Does Not Alter the Presentation or Progression of Robustly Defined Adult-Onset Type 1 Diabetes.

Thomas NJ, Hill AV, Dayan CM, Oram RA, McDonald TJ, Shields BM, Jones AG; StartRight Study Group.Diabetes Care. 2023 Jun 1;46(6):1156-1163. doi: 10.2337/dc22-2159.

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells.

Inaba A, Tuong ZK, Zhao TX, Stewart AP, Mathews R, Truman L, Sriranjan R, Kennet J, Saeb-Parsy K, Wicker L, Waldron-Lynch F, Cheriyan J, Todd JA, Mallat Z, Clatworthy MR.Nat Commun. 2023 Apr 12;14(1):2071. doi: 10.1038/s41467-023-37424-w.

Successful integration of newborn genetic testing into UK routine screening using prospective consent to determine eligibility for clinical trials.

Bendor-Samuel OM, Wishlade T, Willis L, Aley P, Choi E, Craik R, Mujadidi Y, Mounce G, Roseman F, De La Horra Gozalo A, Bland J, Taj N, Smith I, Ziegler AG, Bonifacio E, Winkler C, Haupt F, Todd JA, Servais L, Snape MD, Vatish M; GPPAD Study Group.Arch Dis Child. 2023 Jan;108(1):26-30. doi: 10.1136/archdischild-2022-324270. Epub 2022 Sep 28.

Time Spent in Hypoglycemia According to Age and Time of Day: Observations During Closed-Loop Insulin Delivery.

Alwan H, Ware J, Boughton CK, Wilinska ME, Allen JM, Lakshman R, Nwokolo M, Hartnell S, Bally L, de Beaufort C, Besser REJ, Campbell FM, Davis N, Denvir L, Evans ML, Fröhlich-Reiterer E, Ghatak A, Hofer SE, Kapellen TM, Leelarathna L, Mader JK, Narendran P, Rami-Mehrar B, Tauschmann M, Thabit H, Thankamony A, Hovorka R.Diabetes Technol Ther. 2023 Jun 13. doi: 10.1089/dia.2023.0061. Online ahead of print.

General population screening for paediatric type 1 diabetes-A qualitative study of UK professional stakeholders.

Quinn LM, Narendran P, Randell MJ, Bhavra K, Boardman F, Greenfield SM, Litchfield I.Diabet Med. 2023 May 7:e15131. doi: 10.1111/dme.15131. Online ahead of print.

A UK nationwide study of adults admitted to hospital with diabetic ketoacidosis or hyperosmolar hyperglycaemic state and COVID-19.

Field BCT, Ruan Y, Várnai KA, Davies J, Ryder REJ, Gandhi R, Harris S, Nagi D, Patel D, Kempegowda P, Wild SH, Wilmot EG, Khunti K, Rea R, Narendran P; ABCD COVID-19 Audit Group.Diabetes Obes Metab. 2023 Jul;25(7):2012-2022. doi: 10.1111/dom.15076. Epub 2023 Apr 25.

Factors affecting the support for physical activity in children and adolescents with type 1 diabetes mellitus: a national survey of health care professionals’ perceptions.

Cockcroft EJ, Wooding EL, Narendran P, Dias RP, Barker AR, Moudiotis C, Clarke R, Andrews RC.BMC Pediatr. 2023 Mar 22;23(1):131. doi: 10.1186/s12887-023-03940-3.

Impact of the CamAPS FX hybrid closed-loop insulin delivery system on sleep traits in older adults with type 1 diabetes.

Thabit H, Boughton C, Mubita W, Rubio J, Mader JK, Narendran P, Evans M, Leelarathna L, Wilinska ME, Fullwood C, Gregory AM, Hovorka R, Rutter MK.Diabetes Obes Metab. 2023 Mar;25(3):889-893. doi: 10.1111/dom.14914. Epub 2022 Nov 15.

Differential expression of genes controlling lymphocyte differentiation and migration in two distinct endotypes of type 1 diabetes.

Torabi F, Vadakekolathu J, Wyatt R, Leete P, Tombs MA, Richardson CC, Boocock DJ, Turner MD, Morgan NG, Richardson SJ, Christie MR.Diabet Med. 2023 May 29:e15155. doi: 10.1111/dme.15155. Online ahead of print.

Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants.

Redondo MJ, Richardson SJ, Perry D, Minard CG, Carr ALJ, Brusko T, Kusmartseva I, Pugliese A, Atkinson MA.Diabetologia. 2023 Jan;66(1):127-131. doi: 10.1007/s00125-022-05818-y. Epub 2022 Oct 25.

Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes.

Boldison J, Hopkinson JR, Davies J, Pearson JA, Leete P, Richardson S, Morgan NG, Wong FS.Diabetologia. 2023 Mar;66(3):551-566. doi: 10.1007/s00125-022-05839-7. Epub 2022 Dec 12.

Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes.

McNeilly AD, et al. Diabetologia. 2023. PMID: 37015997.

Psychometric properties of an innovative smartphone application to investigate the daily impact of hypoglycemia in people with type 1 or type 2 diabetes: The Hypo-METRICS app.

Søholm U, Broadley M, Zaremba N, Divilly P, Nefs G, Carlton J, Mader JK, Baumann PM, Gomes M, Martine-Edith G, Pollard DJ, Rath D, Heller S, Pedersen-Bjergaard U, McCrimmon RJ, Renard E, Evans M, de Galan B, Forkmann T, Amiel SA, Hendrieckx C, Speight J, Choudhary P, Pouwer F; Hypo-RESOLVE consortium.PLoS One. 2023 Mar 17;18(3):e0283148. doi: 10.1371/journal.pone.0283148. eCollection 2023.

RESOLVE Consortium.Diabetologia. 2023 Jul;66(7):1340-1352. doi: 10.1007/s00125-023-05907-6. Epub 2023 Apr 4.

Cancer incidence and mortality in 23 000 patients with type 1 diabetes in the UK: Long-term follow-up.

Swerdlow AJ, Jones ME, Slater SD, Burden ACF, Botha JL, Waugh NR, Morris AD, Gatling W, Gillespie KM, Patterson CC, Schoemaker MJ.Int J Cancer. 2023 Aug 1;153(3):512-523. doi: 10.1002/ijc.34548. Epub 2023 May 15.

NLRP6 deficiency expands a novel CD103+ B cell population that confers immune tolerance in NOD mice.

Pearson JA, Peng J, Huang J, Yu X, Tai N, Hu Y, Sha S, Flavell RA, Zhao H, Wong FS, Wen L.Front Immunol. 2023 Feb 23;14:1147925. doi: 10.3389/fimmu.2023.1147925. eCollection 2023.

Islet-specific CD8+ T cells gain effector function in the gut lymphoid tissues via bystander activation not molecular mimicry.

Okada M, Zhang V, Loaiza Naranjo JD, Tillett BJ, Wong FS, Steptoe RJ, Bergot AS, Hamilton-Williams EE.Immunol Cell Biol. 2023 Jan;101(1):36-48. doi: 10.1111/imcb.12593. Epub 2022 Nov 1.

Papers published in 2022

Circulating C-Peptide Levels in Living Children and Young People and Pancreatic β-Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration.

Carr ALJ, Inshaw JRJ, Flaxman CS, Leete P, Wyatt RC, Russell LA, Palmer M, Prasolov D, Worthington T, Hull B, Wicker LS, Dunger DB, Oram RA, Morgan NG, Todd JA, Richardson SJ, Besser REJ. Diabetes. 2022 Jul 1;71(7):1591-1596. doi: 10.2337/db22-0097.PMID: 35499624.

Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.

Sioofy-Khojine AB, Richardson SJ, Locke JM, Oikarinen S, Nurminen N, Laine AP, Downes K, Lempainen J, Todd JA, Veijola R, Ilonen J, Knip M, Morgan NG, Hyöty H, Peakman M, Eichmann M.Diabetologia. 2022 Oct;65(10):1701-1709. doi: 10.1007/s00125-022-05753-y. Epub 2022 Jul 22.PMID: 35867130.

Images From the Exeter Archival Diabetes Biobank Now Accessible via Pancreatlas.

Morgan NG, Richardson SJ, Powers AC, Saunders DC, Brissova M.Diabetes Care. 2022 Dec 1;45(12):e174-e175. doi: 10.2337/dc22-1613.PMID: 36239401.

Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes.

Liu YF, Powrie J, Arif S, Yang JHM, Williams E, Khatri L, Joshi M, Lhuillier L, Fountoulakis N, Smith E, Beam C, Lorenc A, Peakman M, Tree T.Diabetes. 2022 Apr 1;71(4):722-732. doi: 10.2337/db21-0728.PMID: 35073398.

Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism.

Wakeling MN, Owens NDL, Hopkinson JR, Johnson MB, Houghton JAL, Dastamani A, Flaxman CS, Wyatt RC, Hewat TI, Hopkins JJ, Laver TW, van Heugten R, Weedon MN, De Franco E, Patel KA, Ellard S, Morgan NG, Cheesman E, Banerjee I, Hattersley AT, Dunne MJ; International Congenital Hyperinsulinism Consortium; Richardson SJ, Flanagan SE.Nat Genet. 2022 Nov;54(11):1615-1620. doi: 10.1038/s41588-022-01204-x. Epub 2022 Nov 4.PMID: 36333503.

The measurement of autoantibodies to insulin informs diagnosis of diabetes in a childhood population negative for other autoantibodies.

Williams CL, Aitken RJ, Wilson IV, Mortimer GLM, Long AE, Williams AJK; BOX Study Group; Gillespie KM.Diabet Med. 2022 Dec;39(12):e14979. doi: 10.1111/dme.14979. Epub 2022 Oct 30.PMID: 36251483.

Educational Attainment and Childhood-Onset Type 1 Diabetes.

French R, Kneale D, Warner JT, Robinson H, Rafferty J, Sayers A, Taylor P, Gregory JW, Dayan CM.Diabetes Care. 2022 Dec 1;45(12):2852-2861. doi: 10.2337/dc21-0693.

Prescribing costs of hypoglycaemic agents and associations with metabolic control in Wales; a national analysis of primary care data.

Taylor PN, Siah QZ, Marei O, McDade-Kumar M, Rachedi N, Bracchi R, Boldero R, Haines K, Ali MA, French R, Dayan CM.Diabet Med. 2022 Sep;39(9):e14908. doi: 10.1111/dme.14908. Epub 2022 Jul 19.

EarLy Surveillance for Autoimmune diabetes: protocol for a qualitative study of general population and stakeholder perspectives on screening for type 1 diabetes in the UK (ELSA 1).

Quinn LM, Shukla D, Greenfield SM, Barrett T, Garstang J, Boardman F, Litchfield I, Dayan C, Gardner C, Connop C, Lepley A, Narendran P.BMJ Open Diabetes Res Care. 2022 Apr;10(2):e002750. doi: 10.1136/bmjdrc-2021-002750.

Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.

Zhang JY, Hamey F, Trzupek D, Mickunas M, Lee M, Godfrey L, Yang JHM, Pekalski ML, Kennet J, Waldron-Lynch F, Evans ML, Tree TIM, Wicker LS, Todd JA, Ferreira RC.Nat Commun. 2022 Nov 28;13(1):7324. doi: 10.1038/s41467-022-34162-3.

Elevations in blood glucose before and after the appearance of islet autoantibodies in children.

Warncke K, Weiss A, Achenbach P, von dem Berge T, Berner R, Casteels K, Groele L, Hatzikotoulas K, Hommel A, Kordonouri O, Elding Larsson H, Lundgren M, Marcus BA, Snape MD, Szypowska A, Todd JA, Bonifacio E, Ziegler AG; GPPAD and POInT Study Groups.J Clin Invest. 2022 Oct 17;132(20):e162123. doi: 10.1172/JCI162123.

Genetic regulation of RNA splicing in human pancreatic islets.

Atla G, Bonàs-Guarch S, Cuenca-Ardura M, Beucher A, Crouch DJM, Garcia-Hurtado J, Moran I; T2DSystems Consortium; Irimia M, Prasad RB, Gloyn AL, Marselli L, Suleiman M, Berney T, de Koning EJP, Kerr-Conte J, Pattou F, Todd JA, Piemonti L, Ferrer J.Genome Biol. 2022 Sep 15;23(1):196. doi: 10.1186/s13059-022-02757-0.

Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants.

Sandholm N, Rubio García A, Pekalski ML, Inshaw JRJ, Cutler AJ, Todd JA.Sci Rep. 2022 Aug 19;12(1):14137. doi: 10.1038/s41598-022-18296-4.

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus.

Trzupek D, Lee M, Hamey F, Wicker LS, Todd JA, Ferreira RC.Wellcome Open Res. 2022 May 12;6:149. doi: 10.12688/wellcomeopenres.16883.2. eCollection 2021.

Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach.

Richardson TG, Crouch DJM, Power GM, Morales-Berstein F, Hazelwood E, Fang S, Cho Y, Inshaw JRJ, Robertson CC, Sidore C, Cucca F, Rich SS, Todd JA, Davey Smith G.Nat Commun. 2022 Apr 28;13(1):2337. doi: 10.1038/s41467-022-29932-y.

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity.

Wang CJ, Petersone L, Edner NM, Heuts F, Ovcinnikovs V, Ntavli E, Kogimtzis A, Fabri A, Elfaki Y, Houghton LP, Hosse RJ, Schubert DA, Frei AP, Ross EM, Walker LSK.Nat Commun. 2022 Nov 9;13(1):6757. doi: 10.1038/s41467-022-34477-1.

Therapeutic gene editing of T cells to correct CTLA-4 insufficiency.

Fox TA, Houghton BC, Petersone L, Waters E, Edner NM, McKenna A, Preham O, Hinze C, Williams C, de Albuquerque AS, Kennedy A, Pesenacker AM, Genovese P, Walker LSK, Burns SO, Sansom DM, Booth C, Morris EC.Sci Transl Med. 2022 Oct 26;14(668):eabn5811. doi: 10.1126/scitranslmed.abn5811. Epub 2022 Oct 26.

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation.

Kennedy A, Waters E, Rowshanravan B, Hinze C, Williams C, Janman D, Fox TA, Booth C, Pesenacker AM, Halliday N, Soskic B, Kaur S, Qureshi OS, Morris EC, Ikemizu S, Paluch C, Huo J, Davis SJ, Boucrot E, Walker LSK, Sansom DM.Nat Immunol. 2022 Sep;23(9):1365-1378. doi: 10.1038/s41590-022-01289-w. Epub 2022 Aug 23.

Safety of User-Initiated Intensification of Insulin Delivery Using Cambridge Hybrid Closed-Loop Algorithm.

Ware J, Wilinska ME, Ruan Y, Allen JM, Boughton CK, Hartnell S, Bally L, de Beaufort C, Besser REJ, Campbell FM, Draxlbauer K, Elleri D, Evans ML, Fröhlich-Reiterer E, Ghatak A, Hofer SE, Kapellen TM, Leelarathna L, Mader JK, Mubita WM, Narendran P, Poettler T, Rami-Merhar B, Tauschmann M, Randell T, Thabit H, Thankamony A, Trevelyan N, Hovorka R.J Diabetes Sci Technol. 2022 Dec 8:19322968221141924. doi: 10.1177/19322968221141924. Online ahead of print.

Setting up a centralised DKA registry: a leap towards coordinating DKA management in the UK.

Rengarajan LN, Cooper C, Birchenough A, Hebbar M, Pan CSC, Sheikh H, De P, Narendran P.Future Healthc J. 2022 Jul;9(Suppl 2):101. doi: 10.7861/fhj.9-2-s101.

Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes.

Leelarathna L, Evans ML, Neupane S, Rayman G, Lumley S, Cranston I, Narendran P, Barnard-Kelly K, Sutton CJ, Elliott RA, Taxiarchi VP, Gkountouras G, Burns M, Mubita W, Kanumilli N, Camm M, Thabit H, Wilmot EG; FLASH-UK Trial Study Group.N Engl J Med. 2022 Oct 20;387(16):1477-1487. doi: 10.1056/NEJMoa2205650. Epub 2022 Oct 5.

Hybrid closed-loop glucose control compared with sensor augmented pump therapy in older adults with type 1 diabetes: an open-label multicentre, multinational, randomised, crossover study.

Boughton CK, Hartnell S, Thabit H, Mubita WM, Draxlbauer K, Poettler T, Wilinska ME, Hood KK, Mader JK, Narendran P, Leelarathna L, Evans ML, Hovorka R.Lancet Healthy Longev. 2022 Mar;3(3):e135-e142. doi: 10.101/S2666-7568(22)00005-8. Epub 2022 Mar 7.

The clinical profile and associated mortality in people with and without diabetes with Coronavirus disease 2019 on admission to acute hospital services.

Gokhale K, Mostafa SA, Wang J, Tahrani AA, Sainsbury CA, Toulis KA, Thomas GN, Hassan-Smith Z, Sapey E, Gallier S, Adderley NJ, Narendran P, Bellary S, Taverner T, Ghosh S, Nirantharakumar K, Hanif W.Endocrinol Diabetes Metab. 2022 Jan;5(1):e00309. doi: 10.1002/edm2.309. Epub 2021 Dec 3.

Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes.

Liu YF, Powrie J, Arif S, Yang JHM, Williams E, Khatri L, Joshi M, Lhuillier L, Fountoulakis N, Smith E, Beam C, Lorenc A, Peakman M, Tree T.Diabetes. 2022 Apr 1;71(4):722-732. doi: 10.2337/db21-0728.

Live enteroviruses, but not other viruses, detected in human pancreas at the onset of type 1 diabetes in the DiViD study.

Krogvold L, Genoni A, Puggioni A, Campani D, Richardson SJ, Flaxman CS, Edwin B, Buanes T, Dahl-Jørgensen K, Toniolo A.Diabetologia. 2022 Dec;65(12):2108-2120. doi: 10.1007/s00125-022-05779-2. Epub 2022 Aug 12.

Detection of Antiviral Tissue Responses and Increased Cell Stress in the Pancreatic Islets of Newly Diagnosed Type 1 Diabetes Patients: Results From the DiViD Study.

Krogvold L, Leete P, Mynarek IM, Russell MA, Gerling IC, Lenchik NI, Mathews C, Richardson SJ, Morgan NG, Dahl-Jørgensen K.Front Endocrinol (Lausanne). 2022 Jul 26;13:881997. doi: 10.3389/fendo.2022.881997. eCollection 2022.

Temporal regulation of interferon signalling in human EndoC-βH1 cells.

Dhayal S, Leslie KA, Baity M, Akhbari P, Richardson SJ, Russell MA, Morgan NG.J Mol Endocrinol. 2022 May 19;69(2):299-313. doi: 10.1530/JME-21-0224.

Evaluating the Impact of Applying Personal Glucose Targets in a Closed-Loop System for People With Type 1 Diabetes.

Fattah M, Boughton CK, Ware J, Allen JM, Hartnell S, Willinska ME, Thankamony A, de Beaufort C, Campbell FM, Fröhlich-Reiterer E, Hofer SE, Kapellen TM, Rami-Merhar B, Ghatak A, Randell TL, Besser REJ, Elleri D, Trevelyan N, Denvir Md L, Davis N, Bally L, Thabit H, Leelarathna L, Evans ML, Mader JK, Hovorka R.J Diabetes Sci Technol. 2022 Dec 20:19322968221145184. doi: 10.1177/19322968221145184. Online ahead of print.

The emotional well-being of parents with children at genetic risk for type 1 diabetes before and during participation in the POInT-study.

Houben J, Janssens M, Winkler C, Besser REJ, Dzygalo K, Fehn A, Hommel A, Lange K, Elding Larsson H, Lundgren M, Roloff F, Snape M, Szypowska A, Weiss A, Zapardiel-Gonzalo J, Zubizarreta N, Ziegler AG, Casteels K; GPPAD study group.Pediatr Diabetes. 2022 Dec;23(8):1707-1716. doi: 10.1111/pedi.13448.

Closed-Loop Therapy and Preservation of C-Peptide Secretion in Type 1 Diabetes.

Boughton CK, Allen JM, Ware J, Wilinska ME, Hartnell S, Thankamony A, Randell T, Ghatak A, Besser REJ, Elleri D, Trevelyan N, Campbell FM, Sibayan J, Calhoun P, Bailey R, Dunseath G, Hovorka R; CLOuD Consortium.N Engl J Med. 2022 Sep 8;387(10):882-893. doi: 10.1056/NEJMoa2203496.

Lived experience of CamAPS FX closed loop system in youth with type 1 diabetes and their parents.

Hood KK, Garcia-Willingham N, Hanes S, Tanenbaum ML, Ware J, Boughton CK, Allen JM, Wilinska ME, Tauschmann M, Denvir L, Thankamony A, Campbell F, Wadwa RP, Buckingham BA, Davis N, DiMeglio LA, Mauras N, Besser REJ, Ghatak A, Weinzimer SA, Fox DS, Kanapka L, Kollman C, Sibayan J, Beck RW, Hovorka R; DAN05 Consortium.Diabetes Obes Metab. 2022 Dec;24(12):2309-2318. doi: 10.1111/dom.14815. Epub 2022 Aug 8.

Additional insulin dosing for fat and protein in children with type 1 diabetes using multiple daily injections.

Frohock AM, Oke J, Yaliwal C, Edge J, Besser REJ.Pediatr Diabetes. 2022 Sep;23(6):742-748. doi: 10.1111/pedi.13372. Epub 2022 Jun 14.

Cambridge hybrid closed-loop algorithm in children and adolescents with type 1 diabetes: a multicentre 6-month randomised controlled trial.

Ware J, Boughton CK, Allen JM, Wilinska ME, Tauschmann M, Denvir L, Thankamony A, Campbell FM, Wadwa RP, Buckingham BA, Davis N, DiMeglio LA, Mauras N, Besser REJ, Ghatak A, Weinzimer SA, Hood KK, Fox DS, Kanapka L, Kollman C, Sibayan J, Beck RW, Hovorka R; DAN05 Consortium.Lancet Digit Health. 2022 Apr;4(4):e245-e255. doi: 10.1016/S2589-7500(22)00020-6. Epub 2022 Mar 7.

Reductions in HbA1c with Flash Glucose Monitoring Are Sustained for up to 24 Months: A Meta-Analysis of 75 Real-World Observational Studies.

Evans M, Welsh Z, Seibold A.Diabetes Ther. 2022 Jun;13(6):1175-1185. doi: 10.1007/s13300-022-01253-9. Epub 2022 Apr 27.

Advanced hybrid closed loop therapy versus conventional treatment in adults with type 1 diabetes (ADAPT): a randomised controlled study.

Choudhary P, Kolassa R, Keuthage W, Kroeger J, Thivolet C, Evans M, Ré R, de Portu S, Vorrink L, Shin J, Habteab A, Castañeda J, da Silva J, Cohen O; ADAPT study Group.Lancet Diabetes Endocrinol. 2022 Oct;10(10):720-731. doi: 10.1016/S2213-8587(22)00212-1. Epub 2022.

Consistent Effects of Hypoglycemia on Cognitive Function in People With or Without Diabetes.

Verhulst CEM, Fabricius TW, Nefs G, Kessels RPC, Pouwer F, Teerenstra S, Tack CJ, Broadley MM, Kristensen PL, McCrimmon RJ, Heller S, Evans ML, Pedersen-Bjergaard U, de Galan BE.Diabetes Care. 2022 Sep 1;45(9):2103-2110. doi: 10.2337/dc21-2502.

Hypo-METRICS: Hypoglycaemia-MEasurement, ThResholds and ImpaCtS-A multi-country clinical study to define the optimal threshold and duration of sensor-detected hypoglycaemia that impact the experience of hypoglycaemia, quality of life and health economic outcomes: The study protocol.

Divilly P, Zaremba N, Mahmoudi Z, Søholm U, Pollard DJ, Broadley M, Abbink EJ, de Galan B, Pedersen-Bjergaard U, Renard E, Evans M, Speight J, Brennan A, McCrimmon RJ, Müllenborn M, Heller S, Seibold A, Mader JK, Amiel SA, Pouwer F, Choudhary P; Hypo-RESOLVE Consortium.Diabet Med. 2022 Sep;39(9):e14892. doi: 10.1111/dme.14892. Epub 2022 Jun 22.

Implementation of dapagliflozin as adjunctive therapy in type 1 diabetes: A single centre real-world experience.

Raj A, Bansiya V, Evans ML, Boughton CK.Diabet Med. 2022 Jun;39(6):e14764. doi: 10.1111/dme.14764. Epub 2021 Dec 16.

Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes.

Boldison J, Long AE, Aitken RJ, Wilson IV, Megson C, Hanna SJ, Wong FS, Gillespie KM.Diabetologia. 2022 Feb;65(2):343-355. doi: 10.1007/s00125-021-05595-0. Epub 2021 Oct 28.

The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic variants.

Williams CL, Fareed R, Mortimer GLM, Aitken RJ, Wilson IV, George G, Gillespie KM, Williams AJK; BOX Study Group; Long AE.Clin Exp Immunol. 2022 Dec 15;210(2):151-162. doi: 10.1093/cei/uxac087.

Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes.

Di Bonito P, Rosanio FM, Marcovecchio ML, Cherubini V, Delvecchio M, Di Candia F, Iafusco D, Zanfardino A, Iovane B, Maffeis C, Maltoni G, Ripoli C, Piccinno E, Piona CA, Ricciardi MR, Schiaffini R, Franzese A, Mozzillo E.Sci Rep. 2022 Jul 15;12(1):12153. doi: 10.1038/s41598-022-15484-0.

Urinary albumin/creatinine ratio tertiles predict risk of diabetic retinopathy progression: a natural history study from the Adolescent Cardio-Renal Intervention Trial (AdDIT) observational cohort.

Benitez-Aguirre PZ, Marcovecchio ML, Chiesa ST, Craig ME, Wong TY, Davis EA, Cotterill A, Couper JJ, Cameron FJ, Mahmud FH, Neil HAW, Jones TW, Hodgson LAB, Dalton RN, Marshall SM, Deanfield J, Dunger DB, Donaghue KC; Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT).Diabetologia. 2022 May;65(5):872-878. doi: 10.1007/s00125-022-05661-1. Epub 2022 Feb 19.

Combination therapy with saxagliptin and vitamin D for the preservation of β-cell function in adult-onset type 1 diabetes: a multi-center, randomized, controlled trial.

Yan X, Li X, Liu B, Huang J, Xiang Y, Hu Y, Tang X, Zhang Z, Huang G, Xie Z, Zhou H, Liu Z, Wang X, Leslie RD, Zhou Z.Signal Transduct Target Ther. 2023 Apr 20;8(1):158. doi: 10.1038/s41392-023-01369-9.PMID: 37076476.

Papers published in 2021

Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes.

Rodriguez-Calvo T, Chen YC, Verchere CB, Haataja L, Arvan P, Leete P, Richardson SJ, Morgan NG, Qian WJ, Pugliese A, Atkinson M, Evans-Molina C, Sims EK.Diabetes. 2021 May;70(5):1038-1050. doi: 10.2337/dbi20-0034. Epub 2021 May 4.PMID: 33947721.

Characteristics of repeat non-attenders at Diabetes Eye Screening Wales, a national community-based diabetes-related retinopathy screening service, during 2003-2018.

Thomas RL, Cheung WY, Rafferty JM, Luzio SD, Akbari A, Owens DR. Diabet Med. 2021 Sep;38(9):e14536. doi: 10.1111/dme.14536. Epub 2021 Mar 30.PMID: 33545742.

 Measurement of Peak C-Peptide at Diagnosis Informs Glycemic Control but not Hypoglycemia in Adults With Type 1 Diabetes.

Carr ALJ, Oram RA, Marren SM, McDonald TJ, Narendran P, Andrews RC. J Endocr Soc. 2021 Jul 17;5(10):bvab127. doi: 10.1210/jendso/bvab127. eCollection 2021 Oct 1.

Analysis of overlapping genetic association in type 1 and type 2 diabetes.

Inshaw JRJ, Sidore C, Cucca F, Stefana MI, Crouch DJM, McCarthy MI, Mahajan A, Todd JA.Diabetologia. 2021 Jun;64(6):1342-1347. doi: 10.1007/s00125-021-05428-0. Epub 2021 Apr 8.

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.

Robertson CC, Inshaw JRJ, Onengut-Gumuscu S, Chen WM, Santa Cruz DF, Yang H, Cutler AJ, Crouch DJM, Farber E, Bridges SL Jr, Edberg JC, Kimberly RP, Buckner JH, Deloukas P, Divers J, Dabelea D, Lawrence JM, Marcovina S, Shah AS, Greenbaum CJ, Atkinson MA, Gregersen PK, Oksenberg JR, Pociot F, Rewers MJ, Steck AK, Dunger DB; Type 1 Diabetes Genetics Consortium; Wicker LS, Concannon P, Todd JA, Rich SS.Nat Genet. 2021 Jul;53(7):962-971. doi: 10.1038/s41588-021-00880-5. Epub 2021 Jun 14.

 Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol.

Ziegler AG, Arnolds S, Kölln A, Achenbach P, Berner R, Bonifacio E, Casteels K, Elding Larsson H, Gündert M, Hasford J, Kordonouri O, Lundgren M, Oltarzewski M, Pekalski ML, Pfirrmann M, Snape MD, Szypowska A, Todd JA; GPPAD STUDY GROUP.BMJ Open. 2021 Nov 9;11(11):e052449. doi: 10.1136/bmjopen-2021-052449.

Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes.

Korpos É, Kadri N, Loismann S, Findeisen CR, Arfuso F, Burke GW 3rd, Richardson SJ, Morgan NG, Bogdani M, Pugliese A, Sorokin L.Diabetologia. 2021 Jul;64(7):1626-1641. doi: 10.1007/s00125-021-05453-z. Epub 2021 Apr 29.PMID: 33912981.

 Improving clinical utility of GAD65 autoantibodies by electrochemiluminescence assay and clinical phenotype when identifying autoimmune adult-onset diabetes.

Gu Y, Jia X, Vartak T, Miao D, Dong F, Jerram ST, Rewers M, Ferrara A, Lawrence JM, Yu L, Leslie RD; Action LADA consortium and the Diabetes in Young Adults (DiYA) Study Group.Diabetologia. 2021 Sep;64(9):2052-2060. doi: 10.1007/s00125-021-05492-6. Epub 2021 Jul 16.PMID: 34272582.

Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes.

Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Nelson G, Lenchik N, Akhbari P, Gerling I, Richardson SJ, Rodriguez-Calvo T; nPOD-Virus Group.Sci Adv. 2021 Feb 24;7(9):eabd6527. doi: 10.1126/sciadv.abd6527. Print 2021 Feb.PMID: 33627420.

Phase II multicentre, double-blind, randomised trial of ustekinumab in adolescents with new-onset type 1 diabetes (USTEK1D): trial protocol.

Gregory JW, Carter K, Cheung WY, Holland G, Bowen-Morris J, Luzio S, Dunseath G, Tree T, Yang JHM, Marwaha A, Ali MA, Bashir N, Hutchings HA, Fegan GW, Stenson R, Hiles S, Marques-Jones S, Brown A, Tatovic D, Dayan C.BMJ Open. 2021 Oct 18;11(10):e049595. doi: 10.1136/bmjopen-2021-049595.PMID: 34663658.

Expression of Endogenous Putative TSH Binding Protein in Orbit.

Draman MS, Grennan-Jones F, Taylor P, Muller I, Evans S, Haridas A, Morris DS, Rees DA, Lane C, Dayan C, Zhang L, Ludgate M.Curr Issues Mol Biol. 2021 Oct 27;43(3):1794-1804. doi: 10.3390/cimb43030126.

Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides.

Singh RK, Malosse C, Davies J, Malissen B, Kochba E, Levin Y, Birchall JC, Coulman SA, Mous J, McAteer MA, Dayan CM, Henri S, Wong FS.Nanomedicine. 2021 Feb;32:102321. doi: 10.1016/j.nano.2020.102321. Epub 2020 Oct 23.

Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study.

Deshmukh H, Wilmot EG, Gregory R, Barnes D, Narendran P, Saunders S, Furlong N, Kamaruddin S, Banatwalla R, Herring R, Kilvert A, Patmore J, Walton C, Ryder REJ, Sathyapalan T.Diabetes Obes Metab. 2021 Oct;23(10):2261-2268. doi: 10.1111/dom.14467. Epub 2021 Jun 29.

 Differences in presentation, severity and management of DKA in type 1 and type 2 diabetes during the COVID-19 pandemic.

Wallett L, Kempegowda P, Melson E, Juszczak A, Thomas L, Zhou D, Holmes C, Karamat MA, Ghosh S, Hanif W, Johnson A, Narendran P, Bellary S.Clin Med (Lond). 2021 Mar;21(Suppl 2):1-2. doi: 10.7861/clinmed.21-2-s1.

 A UK nationwide study of people with type 1 diabetes admitted to hospital with COVID-19 infection.

Ruan Y, Ryder REJ, De P, Field BCT, Narendran P, Iqbal A, Gandhi R, Harris S, Nagi D, Aziz U, Karra E, Ghosh S, Hanif W, Edwards AE, Zafar M, Dashora U, Várnai KA, Davies J, Wild SH, Wilmot EG, Webb D, Khunti K, Rea R; ABCD Covid-19 audit group.Diabetologia. 2021 Aug;64(8):1717-1724. doi: 10.1007/s00125-021-05463-x. Epub 2021 May 8.

Effect of COVID-19 on the clinical course of diabetic ketoacidosis (DKA) in people with type 1 and type 2 diabetes.

Kempegowda P, Melson E, Johnson A, Wallett L, Thomas L, Zhou D, Holmes C, Juszczak A, Karamat MA, Ghosh S, Hanif W, Narendran P, Bellary S.Endocr Connect. 2021 Apr;10(4):371-377. doi: 10.1530/EC-20-0567.

 Autoreactive T cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function.

Sabbah S, Liew A, Brooks AM, Kundu R, Reading JL, Flatt A, Counter C, Choudhary P, Forbes S, Rosenthal MJ, Rutter MK, Cairns S, Johnson P, Casey J, Peakman M, Shaw JA, Tree TIM.Am J Transplant. 2021 Mar;21(3):1027-1038. doi: 10.1111/ajt.16285. Epub 2020 Sep 19.

Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects.

Arif S, Pujol-Autonell I, Kamra Y, Williams E, Yusuf N, Domingo-Vila C, Shahrabi Y, Pollock E, Khatri L, Peakman M, Tree T, Lorenc A.Front Immunol. 2021 Jun 25;12:675746. doi: 10.3389/fimmu.2021.675746. eCollection 2021.

Natural Protection From Type 1 Diabetes in NOD Mice Is Characterized by a Unique Pancreatic Islet Phenotype.

Boldison J, Thayer TC, Davies J, Wong FS.Diabetes. 2021 Apr;70(4):955-965. doi: 10.2337/db20-0945. Epub 2021 Feb 2.

Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function.

Huang J, Peng J, Pearson JA, Efthimiou G, Hu Y, Tai N, Xing Y, Zhang L, Gu J, Jiang J, Zhao H, Zhou Z, Wong FS, Wen L.Cell Mol Immunol. 2021 Feb;18(2):328-338. doi: 10.1038/s41423-020-00590-8. Epub 2021 Jan 11.

TLR9 Deficiency in B Cells Promotes Immune Tolerance via Interleukin-10 in a Type 1 Diabetes Mouse Model.

Sha S, Pearson JA, Peng J, Hu Y, Huang J, Xing Y, Zhang L, Zhu Y, Zhao H, Wong FS, Chen L, Wen L.Diabetes. 2021 Feb;70(2):504-515. doi: 10.2337/db20-0373. Epub 2020 Nov 5.

Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes.

Thayer TC, Davies J, Pearson JA, Hanna SJ, Wen L, Wong FS. Diabetes. 2021 Feb;70(2):529-537. doi: 10.2337/db19-1050. Epub 2020 Oct 29.

Expression of CD47 in the pancreatic β-cells of people with recent-onset type 1 diabetes varies according to disease endotype.

Leslie KA, Richardson SJ, Russell MA, Morgan NG.Diabet Med. 2021 Dec;38(12):e14724. doi: 10.1111/dme.14724. Epub 2021 Nov 4.

Localization of enteroviral RNA within the pancreas in donors with T1D and T1D-associated autoantibodies.

Geravandi S, Richardson S, Pugliese A, Maedler K.Cell Rep Med. 2021 Aug 17;2(8):100371. doi: 10.1016/j.xcrm.2021.100371. eCollection 2021 Aug 17.

Adolescents’ Experiences of Using a Smartphone Application Hosting a Closed-loop Algorithm to Manage Type 1 Diabetes in Everyday Life: Qualitative Study.

Rankin D, Kimbell B, Allen JM, Besser REJ, Boughton CK, Campbell F, Elleri D, Fuchs J, Ghatak A, Randell T, Thankamony A, Trevelyan N, Wilinska ME, Hovorka R, Lawton J.J Diabetes Sci Technol. 2021 Sep;15(5):1042-1051. doi: 10.1177/1932296821994201. Epub 2021 Jul 14.

Hybrid Closed-loop to Manage Gastroparesis in People With Type 1 Diabetes: a Case Series.

Daly A, Hartnell S, Boughton CK, Evans M.J Diabetes Sci Technol. 2021 Nov;15(6):1216-1223. doi: 10.1177/19322968211035447. Epub 2021 Aug 11.

Flash glucose monitoring with the FreeStyle Libre 2 compared with self-monitoring of blood glucose in suboptimally controlled type 1 diabetes: the FLASH-UK randomised controlled trial protocol.

Wilmot EG, Evans M, Barnard-Kelly K, Burns M, Cranston I, Elliott RA, Gkountouras G, Kanumilli N, Krishan A, Kotonya C, Lumley S, Narendran P, Neupane S, Rayman G, Sutton C, Taxiarchi VP, Thabit H, Leelarathna L.BMJ Open. 2021 Jul 14;11(7):e050713. doi: 10.1136/bmjopen-2021-050713.

User Engagement With the CamAPS FX Hybrid Closed-Loop App According to Age and User Characteristics.

Chen NS, Boughton CK, Hartnell S, Fuchs J, Allen JM, Willinska ME, Thankamony A, de Beaufort C, Campbell FM, Fröhlich-Reiterer E, Hofer SE, Kapellen TM, Rami-Merhar B, Ghatak A, Randell TL, Besser REJ, Elleri D, Trevelyan N, Denvir L, Davis N, Gurnell E, Lindsay R, Morris D, Scott EM, Bally L, Thabit H, Leelarathna L, Evans ML, Murphy HR, Mader JK, Hovorka R; AiDAPT, AP@home04, CLOuD, DAN05, DAN06, and KidsAP consortia.Diabetes Care. 2021 Jul;44(7):e148-e150. doi: 10.2337/dc20-2762. Epub 2021 May 21.

Day-to-day variability of insulin requirements in the inpatient setting: Observations during fully closed-loop insulin delivery.

Boughton CK, Daly A, Thabit H, Hartnell S, Herzig D, Vogt A, Ruan Y, Wilinska ME, Evans ML, Coll AP, Bally L, Hovorka R.Diabetes Obes Metab. 2021 Aug;23(8):1978-1982. doi: 10.1111/dom.14396. Epub 2021 May 4.

Hybrid closed-loop glucose control with faster insulin aspart compared with standard insulin aspart in adults with type 1 diabetes: A double-blind, multicentre, multinational, randomized, crossover study.

Boughton CK, Hartnell S, Thabit H, Poettler T, Herzig D, Wilinska ME, Ashcroft NL, Sibayan J, Cohen N, Calhoun P, Bally L, Mader JK, Evans M, Leelarathna L, Hovorka R.Diabetes Obes Metab. 2021 Jun;23(6):1389-1396. doi: 10.1111/dom.14355. Epub 2021 Mar 8.

Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes.

Wilhelm-Benartzi CS, Miller SE, Bruggraber S, Picton D, Wilson M, Gatley K, Chhabra A, Marcovecchio ML, Hendriks AEJ, Morobé H, Chmura PJ, Bond S, Aschemeier-Fuchs B, Knip M, Tree T, Overbergh L, Pall J, Arnaud O, Haller MJ, Nitsche A, Schulte AM, Mathieu C, Mander A, Dunger D.BMJ Open. 2021 Dec 7;11(12):e053669. doi: 10.1136/bmjopen-2021-053669.

IL-10 Deficiency Accelerates Type 1 Diabetes Development via Modulation of Innate and Adaptive Immune Cells and Gut Microbiota in BDC2.5 NOD Mice.

Huang J, Tan Q, Tai N, Pearson JA, Li Y, Chao C, Zhang L, Peng J, Xing Y, Zhang L, Hu Y, Zhou Z, Wong FS, Wen L.Front Immunol. 2021 Jul 30;12:702955. doi: 10.3389/fimmu.2021.702955. eCollection 2021.

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes.

Marwaha AK, Chow S, Pesenacker AM, Cook L, Sun A, Long SA, Yang JHM, Ward-Hartstonge KA, Williams E, Domingo-Vila C, Halani K, Harris KM, Tree TIM, Levings MK, Elliott T, Tan R, Dutz JP.Immunother Adv. 2021 Nov 13;2(1):ltab022. doi: 10.1093/immadv/ltab022. eCollection 2022.

Islet autoantibody profiles associated with higher diabetes risk in Lithuanian compared with English schoolchildren.

Long AE, Caygill CH, Gillespie KM, Marčiulionytė D, Williams AJK.Clin Exp Immunol. 2021 Jan;203(1):41-46. doi: 10.1111/cei.13524. Epub 2020 Oct 26.PMID: 32979862.

Selected publications published before 2021

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes.

Cousminer DL, Ahlqvist E, Mishra R, Andersen MK, Chesi A, Hawa MI, Davis A, Hodge KM, Bradfield JP, Zhou K, Guy VC, Åkerlund M, Wod M, Fritsche LG, Vestergaard H, Snyder J, Højlund K, Linneberg A, Käräjämäki A, Brandslund I, Kim CE, Witte D, Sørgjerd EP, Brillon DJ, Pedersen O, Beck-Nielsen H, Grarup N, Pratley RE, Rickels MR, Vella A, Ovalle F, Melander O, Harris RI, Varvel S, Grill VER; Bone Mineral Density in Childhood Study; Hakonarson H, Froguel P, Lonsdale JT, Mauricio D, Schloot NC, Khunti K, Greenbaum CJ, Åsvold BO, Yderstræde KB, Pearson ER, Schwartz S, Voight BF, Hansen T, Tuomi T, Boehm BO, Groop L, Leslie RD, Grant SFA.Diabetes Care. 2018 Nov;41(11):2396-2403. doi: 10.2337/dc18-1032. Epub 2018 Sep 25.PMID: 30254083

Proinsulin in the identification and risk stratification of gestational diabetes mellitus: study protocol for a prospective, longitudinal cohort study.

Peter R, Bright D, Cheung WY, Luzio SD, Dunseath GJ.BMJ Open. 2018 Aug 29;8(8):e022571. doi: 10.1136/bmjopen-2018-022571.PMID: 30158232

Effect of structured self-monitoring of blood glucose, with and without additional TeleCare support, on overall glycaemic control in non-insulin treated Type 2 diabetes: the SMBG Study, a 12-month randomized controlled trial.

Parsons SN, Luzio SD, Harvey JN, Bain SC, Cheung WY, Watkins A, Owens DR. Diabet Med. 2019 May;36(5):578-590. doi: 10.1111/dme.13899. Epub 2019 Feb 18.PMID: 30653704.

Trisomy 21 Is a Cause of Permanent Neonatal Diabetes That Is Autoimmune but Not HLA Associated.

Johnson MB, De Franco E, Greeley SAW, Letourneau LR, Gillespie KM; International DS-PNDM Consortium; Wakeling MN, Ellard S, Flanagan SE, Patel KA, Hattersley AT.Diabetes. 2019 Jul;68(7):1528-1535. doi: 10.2337/db19-0045. Epub 2019 Apr 8.PMID: 30962220.

Persistent C-peptide is associated with reduced hypoglycaemia but not HbA1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?

Marren SM, Hammersley S, McDonald TJ, Shields BM, Knight BA, Hill A, Bolt R, Tree TI, Roep BO, Hattersley AT, Jones AG, Oram RA; TIGI consortium.Diabet Med. 2019 Sep;36(9):1092-1099. doi: 10.1111/dme.13960. Epub 2019 Jun 27.PMID: 30955221.

Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC.

Mishra R, Åkerlund M, Cousminer DL, Ahlqvist E, Bradfield JP, Chesi A, Hodge KM, Guy VC, Brillon DJ, Pratley RE, Rickels MR, Vella A, Ovalle F, Harris RI, Melander O, Varvel S, Hakonarson H, Froguel P, Lonsdale JT, Mauricio D, Schloot NC, Khunti K, Greenbaum CJ, Yderstræde KB, Tuomi T, Voight BF, Schwartz S, Boehm BO, Groop L, Leslie RD, Grant SFA.Diabetes Care. 2020 Feb;43(2):418-425. doi: 10.2337/dc19-0986. Epub 2019 Dec 16.PMID: 31843946.

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells.

Colli ML, Ramos-Rodríguez M, Nakayasu ES, Alvelos MI, Lopes M, Hill JLE, Turatsinze JV, Coomans de Brachène A, Russell MA, Raurell-Vila H, Castela A, Juan-Mateu J, Webb-Robertson BM, Krogvold L, Dahl-Jorgensen K, Marselli L, Marchetti P, Richardson SJ, Morgan NG, Metz TO, Pasquali L, Eizirik DL.Nat Commun. 2020 May 22;11(1):2584. doi: 10.1038/s41467-020-16327-0.PMID: 32444635.

Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells.

Johnson MB, Patel KA, De Franco E, Hagopian W, Killian M, McDonald TJ, Tree TIM, Domingo-Vila C, Hudson M, Hammersley S, Dobbs R; EXE-T1D Consortium; Ellard S, Flanagan SE, Hattersley AT, Oram RA. Diabetologia. 2020 Dec;63(12):2605-2615. doi: 10.1007/s00125-020-05276-4. Epub 2020 Oct 8.PMID: 33029656.

Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel.

Buzzetti R, Tuomi T, Mauricio D, Pietropaolo M, Zhou Z, Pozzilli P, Leslie RD.Diabetes. 2020 Oct;69(10):2037-2047. doi: 10.2337/dbi20-0017. Epub 2020 Aug 26.PMID: 32847960.

Prevalence of admission plasma glucose in ‘diabetes’ or ‘at risk’ ranges in hospital emergencies with no prior diagnosis of diabetes by gender, age and ethnicity.

Ghosh S, Manley SE, Nightingale PG, Williams JA, Susarla R, Alonso-Perez I, Stratton IM, Gkoutos GV, Webber J, Luzio SD, Hanif W, Roberts GA.Endocrinol Diabetes Metab. 2020 May 15;3(3):e00140. doi: 10.1002/edm2.140. eCollection 2020 Jul.PMID: 32704561.